This major summit will focus on the intersection of HIV, viral hepatitis, and substance use in Appalachia and rural communities. CEG will host this event with the following co-hosts: WV Rural Health Association, West Virginia School of Osteopathic Medicine, Virginia Rural Health Association, NC AIDS Action Network, Maryland Rural Health Association, Community Liver Alliance, Community Liver Alliance, Kentucky Rural Health Association, Southern AIDS Coalition, Harm Reduction Ohio, ETSU Addiction Science Center, AIDS Alabama, and Prisma Health.